Purines as potential morphogens during embryonic development
نویسندگان
چکیده
منابع مشابه
Embryonic pattern formation without morphogens.
One of the earliest and most-fundamental pattern- formation events in embryonic development is endoderm and mesoderm specification. In sea urchin embryos, this process begins with blimp1 and wnt8 gene expression at the vegetal pole as soon as embryonic transcription begins. Shortly afterwards, wnt8/blimp1 expression spreads to the adjacent ring of mesoderm progenitor cells and is extinguished i...
متن کاملSystems biology of embryonic morphogens.
A network of secreted proteins that interact with each other in the extracellular space regulates embryonic morphogenesis. Mathematical modeling offers an excellent opportunity to understand how morphogens signal and self-regenerate pattern.
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Hands have five fingers, with each finger different and arranged in a particular order. Obvious perhaps, but the way that this arrangement is achieved during development has intrigued developmental biologists for decades. How do the cells of the hand know whether to form a thumb, index or little finger? More generally, how do cells know where they are within a tissue so that they form the appro...
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BACKGROUND Branching morphogenesis generates a diverse array of epithelial patterns, including dichotomous and monopodial geometries. Dichotomous branching can be instructed by concentration gradients of epithelial-derived inhibitory morphogens, including transforming growth factor-β (TGFβ), which is responsible for ramification of the pubertal mammary gland. Here, we investigated the role of a...
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Morphogen family proteins are now widely appreciated as axon guidance cues. Because their roles as morphogens are highly conserved across phylogeny, their functional conservation in axon guidance is now being rigorously examined. Recent studies suggest that morphogens are important in shaping topographic projections in chick and Drosophila visual systems, a process that occurs even later in dev...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2012
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-012-9290-y